Nature Communications (Jul 2018)
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
- Erika López-Arribillaga,
- Verónica Rodilla,
- Carlota Colomer,
- Anna Vert,
- Amy Shelton,
- Jason H. Cheng,
- Bing Yan,
- Abel Gonzalez-Perez,
- Melissa R. Junttila,
- Mar Iglesias,
- Ferran Torres,
- Joan Albanell,
- Alberto Villanueva,
- Anna Bigas,
- Christian W. Siebel,
- LLuís Espinosa
Affiliations
- Erika López-Arribillaga
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Verónica Rodilla
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Carlota Colomer
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Anna Vert
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Amy Shelton
- Department of Discovery Oncology, Genentech, Inc.
- Jason H. Cheng
- Department of Discovery Oncology, Genentech, Inc.
- Bing Yan
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Abel Gonzalez-Perez
- Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra
- Melissa R. Junttila
- Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco
- Mar Iglesias
- Department of Pathology, Hospital del Mar
- Ferran Torres
- Universitat Autonoma of Barcelona
- Joan Albanell
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Alberto Villanueva
- Laboratori de Recerca Translacional, IDIBELL-Institut Català d’Oncologia Gran Via km 2.7, Hospitalet
- Anna Bigas
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- Christian W. Siebel
- Department of Discovery Oncology, Genentech, Inc.
- LLuís Espinosa
- Cancer Research Program. CIBERONC. Institut Mar d’Investigacions Mèdiques, Hospital del Mar
- DOI
- https://doi.org/10.1038/s41467-018-05385-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients
