Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles

Hannah O. Ajoge; Tyler M. Renner; Kasandra Bélanger; Matthew Greig; Samar Dankar; Hinissan P. Kohio; Macon D. Coleman; Emmanuel Ndashimye; Eric J. Arts; Marc-André Langlois; Stephen D. Barr

doi:10.1038/s41467-022-35379-y

Nature Communications (Jan 2023)

Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles

Hannah O. Ajoge,
Tyler M. Renner,
Kasandra Bélanger,
Matthew Greig,
Samar Dankar,
Hinissan P. Kohio,
Macon D. Coleman,
Emmanuel Ndashimye,
Eric J. Arts,
Marc-André Langlois,
Stephen D. Barr

Affiliations

Hannah O. Ajoge: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology
Tyler M. Renner: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
Kasandra Bélanger: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
Matthew Greig: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
Samar Dankar: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
Hinissan P. Kohio: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology
Macon D. Coleman: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology
Emmanuel Ndashimye: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology
Eric J. Arts: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology
Marc-André Langlois: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
Stephen D. Barr: Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology

DOI: https://doi.org/10.1038/s41467-022-35379-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

Read online

Antiretroviral APOBEC3 may contribute to HIV-1 latency. In this study, Ajoge and Renner et al. identify a previously undescribed function of human APOBEC3 proteins in redirecting integrations of HIV-1 DNA into more transcriptionally inactive regions of the genome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal