Genetic predictors of obstetric complications: intergenetic association

Abstract

The goal of the research is to analyze the intergenic interaction of the marker-genes of thrombophilia, the disruption of gomocystein cycle and blood pressure control. Two groups of women have been included in the investigation. The under study group consists of 197 women with eclampcy and pregnancy miscarriage in anamnesis. The comparison group consists of 228 women with normal obstetric anamnesis. The molecular-genetic analysis of 21 allelic polymorphisms of MTHFR, MTR, MTRR, FGB, F2, F5, F7, F13, ITGA2, ITGB3, PAI-1, ADD1, AGT, AGTR1, AGTR2, CYP, GNB, NOS3 genes has been carried out. Statistically significant differences haven’t been revealed in the univariate analysis of the alternative genotypes rate between groups. However, we have found out that the frequency of combined genotypes (AGT 704CC, GNB 825CT, NOS3 894GT, MTR 2756AG) in group with eclampcy and pregnancy miscarriage in anamnesis is statistically higher.

Keywords

• полиморфизм генов
• комбинированный генотип