Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

Yumei Gong; Peirun Song; Xinyu Du; Yuying Zhai; Haoxuan Xu; Hangting Ye; Xuehui Bao; Qianyue Huang; Zhiyi Tu; Pei Chen; Xuan Zhao; David Pérez-González; Manuel S. Malmierca; Xiongjie Yu

Cell Reports (Mar 2024)

Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

Yumei Gong,
Peirun Song,
Xinyu Du,
Yuying Zhai,
Haoxuan Xu,
Hangting Ye,
Xuehui Bao,
Qianyue Huang,
Zhiyi Tu,
Pei Chen,
Xuan Zhao,
David Pérez-González,
Manuel S. Malmierca,
Xiongjie Yu

Affiliations

Yumei Gong: Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China; Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Hangzhou Extremely Weak Magnetic Field Major Science and Technology, Infrastructure Research Institute, Hangzhou 310000, China; Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical, Engineering, and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China
Peirun Song: Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Xinyu Du: Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Yuying Zhai: Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Haoxuan Xu: Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical, Engineering, and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China
Hangting Ye: Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Xuehui Bao: Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical, Engineering, and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China
Qianyue Huang: Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical, Engineering, and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China
Zhiyi Tu: Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China
Pei Chen: Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China
Xuan Zhao: Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China
David Pérez-González: Cognitive and Auditory Neuroscience Laboratory (Lab 1), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Department of Basic Psychology, Psychobiology, and Methodology of Behavioral Sciences, Faculty of Psychology, University of Salamanca, Salamanca, Spain
Manuel S. Malmierca: Cognitive and Auditory Neuroscience Laboratory (Lab 1), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain; Corresponding author
Xiongjie Yu: Department of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China; Department of Anesthesia, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Corresponding author

Journal volume & issue: Vol. 43, no. 3
p. 113864

Abstract

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Summary: The neural mechanisms underlying novelty detection are not well understood, especially in relation to behavior. Here, we present single-unit responses from the primary auditory cortex (A1) from two monkeys trained to detect deviant tones amid repetitive ones. Results show that monkeys can detect deviant sounds, and there is a strong correlation between late neuronal responses (250–350 ms after deviant onset) and the monkeys’ perceptual decisions. The magnitude and timing of both neuronal and behavioral responses are increased by larger frequency differences between the deviant and standard tones and by increasing the number of standard tones preceding the deviant. This suggests that A1 neurons encode novelty detection in behaving monkeys, influenced by stimulus relevance and expectations. This study provides evidence supporting aspects of predictive coding in the sensory cortex.

CP: Neuroscience

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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