Journal of International Medical Research (Oct 2020)

Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: an adult case report and literature review

  • Yuxiong Wang,
  • Yuantao Wang,
  • Mingliang Feng,
  • Xin Lian,
  • Yongsheng Lei,
  • Honglan Zhou

DOI
https://doi.org/10.1177/0300060520942095
Journal volume & issue
Vol. 48

Abstract

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Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 ( TFE3 ) gene fusion is a rare and independent subtype of RCC included in the classification of MiT (microphthalmia-associated transcriptional factor) family translocation RCC. Herein, we report an adult case of Xp11.2 translocation RCC, and review the relevant literature to improve our understanding of the pathogenesis, epidemiology, clinical manifestations, diagnosis, differential diagnosis, treatment, and other aspects of the disease.