Electrophotochemical metal-catalyzed synthesis of alkylnitriles from simple aliphatic carboxylic acids

Abstract

We report a practical and sustainable electrophotochemical metal-catalyzed protocol for decarboxylative cyanation of simple aliphatic carboxylic acids. This environmentally friendly method features easy availability of substrates, broad functional group compatibility, and directly converts a diverse range of aliphatic carboxylic acids including primary and tertiary alkyl acids into synthetically versatile alkylnitriles without using chemical oxidants or costly cyanating reagents under mild reaction conditions.

Keywords

• aliphatic carboxylic acids
• alkylnitriles
• electroorganic synthesis
• electrophotocatalysis
• radical decarboxylation