Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium <i>Moorea Producens</i>

Abstract

A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.

Keywords

• cyanobacteria
• aplysiatoxin
• <i>moorea producens</i>
• cytotoxicity
• bioactivity