Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions

Masayuki Nakajima; Masashi Matsuyama; Mio Kawaguchi; Takumi Kiwamoto; Yosuke Matsuno; Yuko Morishima; Kazufumi Yoshida; Mingma Sherpa; Kai Yazaki; Hajime Osawa; Masafumi Muratani; Yukio Ishii; Nobuyuki Hizawa

doi:10.1128/mBio.01947-20

mBio (Feb 2021)

Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions

Masayuki Nakajima,
Masashi Matsuyama,
Mio Kawaguchi,
Takumi Kiwamoto,
Yosuke Matsuno,
Yuko Morishima,
Kazufumi Yoshida,
Mingma Sherpa,
Kai Yazaki,
Hajime Osawa,
Masafumi Muratani,
Yukio Ishii,
Nobuyuki Hizawa

Affiliations

Masayuki Nakajima: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Masashi Matsuyama: ORCiD; Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Mio Kawaguchi: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Takumi Kiwamoto: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Yosuke Matsuno: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Yuko Morishima: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Kazufumi Yoshida: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Mingma Sherpa: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Kai Yazaki: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Hajime Osawa: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Masafumi Muratani: Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
Yukio Ishii: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Nobuyuki Hizawa: Department of Respiratory Medicine, Division of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

DOI: https://doi.org/10.1128/mBio.01947-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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Nontuberculous mycobacteria (NTM) are an important cause of morbidity and mortality in pulmonary infections. Among them, Mycobacterium avium

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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