Effects of Infection with Different Types of Helicobacter pylori on Gastric Secretion Function: A Cross-Sectional Clinical Study

Abstract

Jinglei Wang,1 Dehong Qiao,2 Yunzhu Wang,3 Rui Xiong,1 Xinyi Ding,1 Wei Zhang,3 Tingting Wang,1 Kai Tang1 1Department of Gastroenterology, Zhejiang Rongjun Hospital, Jiaxing, People’s Republic of China; 2Minimally Invasive Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, Jiaxing, People’s Republic of China; 3Endoscopy Center, Zhejiang Rongjun Hospital, Jiaxing, People’s Republic of ChinaCorrespondence: Kai Tang, Department of Gastroenterology, Zhejiang Rongjun Hospital, Jiaxing, People’s Republic of China, [phone], Email [email protected]: Helicobacter pylori (Hp)-related gastropathies are accompanied by alterations in gastric secretion function, but the effects of infection of different Hp strains on gastric function are not yet well-elucidated. Our cross-sectional clinical study aim to research the effects of infection with different Hp types on gastric function.Patients and Methods: We analyzed 525 patients’ serum cytotoxin-associated protein gene A (CagA), vacuolating cytotoxin-associated protein gene A (VacA), urease (Ure), Gastrin-17 (G-17), Pepsinogen I (PGI), Pepsinogen II (PGII) and PGI/PGII ratio (PGR).Results: The PGII levels (8.19 ± 5.44 vs 5.98 ± 10.75, P = 0.013) were higher in the Hp infected group than in the uninfected, while the PGR levels (16.81 ± 8.22 vs 23.23 ± 8.36, P < 0.001) were lower. The PGR levels were higher in the uninfected group (23.23 ± 8.36, P < 0.001) than in Hp-I (16.47 ± 7.45) and Hp-II infected groups (17.39 ± 8.98). In the uninfected group, the G-17 level was positively correlated with the levels of PGI (Pearson coefficient = 0.177, P = 0.001), PGII (Pearson coefficient = 0.140, P = 0.008) and age (Pearson coefficient = 0.121, P = 0.022), negatively with the PGR levels (Pearson coefficient = − 0.201, P < 0.001). In the Hp-I (Pearson coefficient = − 0.003, P = 0.975) and Hp-II (Pearson coefficient = 0.018, P = 0.161) infected groups, the G-17 levels were not correlated with age.Conclusion: Hp-I with CagA and/or VacA positive and Hp-II without cytotoxicity can reduce gastric secretion function regardless of age and sex. Gastric function in patients with Hp eradication was similar to that in those without Hp infection. G-17 rises physiologically with age, but infection with Hp will affect it.Keywords: Helicobacter pylori, Pepsinogen I, Pepsinogen II, Gastrin-17, cytotoxin-associated protein gene A, vacuolating cytotoxin-associated protein gene A

Keywords

• helicobacter pylori
• pepsinogen i
• pepsinogen ii
• gastrin-17
• cytotoxin-associated protein gene a
• vacuolating cytotoxin-associated protein gene a