Nature Communications (Jun 2021)

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

  • Xiaoping Xu,
  • Kai Ni,
  • Yafeng He,
  • Jianke Ren,
  • Chongkui Sun,
  • Yie Liu,
  • Mirit I. Aladjem,
  • Sandra Burkett,
  • Richard Finney,
  • Xia Ding,
  • Shyam K. Sharan,
  • Kathrin Muegge

DOI
https://doi.org/10.1038/s41467-021-23809-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.