Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

Ryuichi Hirota; Toru Murayama; Ryota Katsumi; Tokuhisa Kawawaki; Shin Yabukami; Ryuji Igarashi; Yuichi Negishi; Moriaki Kusakabe; Masaki Sekino; Takashi Yatsui; Akihiro Kuwahata

doi:10.1063/9.0000483

AIP Advances (Feb 2023)

Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

Ryuichi Hirota,
Toru Murayama,
Ryota Katsumi,
Tokuhisa Kawawaki,
Shin Yabukami,
Ryuji Igarashi,
Yuichi Negishi,
Moriaki Kusakabe,
Masaki Sekino,
Takashi Yatsui,
Akihiro Kuwahata

Affiliations

Ryuichi Hirota: Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan
Toru Murayama: Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan
Ryota Katsumi: Graduate School of Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan
Tokuhisa Kawawaki: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan
Shin Yabukami: Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan
Ryuji Igarashi: Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Yuichi Negishi: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan
Moriaki Kusakabe: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Masaki Sekino: Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
Takashi Yatsui: Graduate School of Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan
Akihiro Kuwahata: Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan

DOI: https://doi.org/10.1063/9.0000483
Journal volume & issue: Vol. 13, no. 2
pp. 025144 – 025144-5

Abstract

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Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.

Published in AIP Advances

ISSN: 2158-3226 (Online)
Publisher: AIP Publishing LLC
Country of publisher: United States
LCC subjects: Science: Physics
Website: http://aipadvances.aip.org/

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