Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Ake T. Lu; Eilis Hannon; Morgan E. Levine; Eileen M. Crimmins; Katie Lunnon; Jonathan Mill; Daniel H. Geschwind; Steve Horvath

doi:10.1038/ncomms15353

Nature Communications (May 2017)

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Ake T. Lu,
Eilis Hannon,
Morgan E. Levine,
Eileen M. Crimmins,
Katie Lunnon,
Jonathan Mill,
Daniel H. Geschwind,
Steve Horvath

Affiliations

Ake T. Lu: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
Eilis Hannon: University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road
Morgan E. Levine: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
Eileen M. Crimmins: Davis School of Gerontology, University of Southern California, Ethel Percy Andrus Gerontology Center
Katie Lunnon: University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road
Jonathan Mill: University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road
Daniel H. Geschwind: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
Steve Horvath: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles

DOI: https://doi.org/10.1038/ncomms15353
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Studies on the ‘epigenetic clock’, a recently identified ageing biomarker, suggest that pathology might be linked to tissue-specific accelerated ageing. Here, the authors investigate ageing in the human brain and identify genetic loci associated with accelerated ageing in different brain regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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