Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Jul 2024)

CLEAR Thrombectomy Score: An Index to Estimate the Probability of Good Functional Outcome With or Without Endovascular Treatment in the Late Window for Anterior Circulation Occlusion

  • James E. Siegler,
  • Manisha Koneru,
  • Muhammad M. Qureshi,
  • Mohamed Doheim,
  • Raul G. Nogueira,
  • Nicolas Martinez‐Majander,
  • Simon Nagel,
  • Mary Penckofer,
  • Jelle Demeestere,
  • Volker Puetz,
  • Marc Ribo,
  • Mohamad Abdalkader,
  • João Pedro Marto,
  • Alhamza R. Al‐Bayati,
  • Hiroshi Yamagami,
  • Diogo C. Haussen,
  • Marta Olive‐Gadea,
  • Simon Winzer,
  • Mahmoud H. Mohammaden,
  • Robin Lemmens,
  • Kanta Tanaka,
  • Pekka Virtanen,
  • Anne Dusart,
  • Flavio Bellante,
  • Daniel P. O. Kaiser,
  • Francois Caparros,
  • Hilde Henon,
  • João Nuno Ramos,
  • Santiago Ortega‐Gutierrez,
  • Sunil A. Sheth,
  • Stefania Nannoni,
  • Lieselotte Vandewalle,
  • Johannes Kaesmacher,
  • Sergio Salazar‐Marioni,
  • Liisa Tomppo,
  • Rita Ventura,
  • Syed F. Zaidi,
  • Mouhammad Jumaa,
  • Alicia C. Castonguay,
  • Milagros Galecio‐Castillo,
  • Ajit S. Puri,
  • Adnan Mujanovic,
  • Piers Klein,
  • Liqi Shu,
  • Behzad Farzin,
  • Hannah Moomey,
  • Hesham E. Masoud,
  • Jessica Jesser,
  • Markus A. Möhlenbruch,
  • Peter A. Ringleb,
  • Daniel Strbian,
  • Osama O. Zaidat,
  • Shadi Yaghi,
  • Davide Strambo,
  • Patrik Michel,
  • Daniel Roy,
  • Shinichi Yoshimura,
  • Kazutaka Uchida,
  • Jean Raymond,
  • Thanh N. Nguyen

DOI
https://doi.org/10.1161/JAHA.124.034948
Journal volume & issue
Vol. 13, no. 14

Abstract

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Background With the expanding eligibility for endovascular therapy (EVT) of patients presenting in the late window (6–24 hours after last known well), we aimed to derive a score to predict favorable outcomes associated with EVT versus best medical management. Methods and Results A multinational observational cohort of patients from the CLEAR (Computed Tomography for Late Endovascular Reperfusion) study with proximal intracranial occlusion (2014–2022) was queried (n=58 sites). Logistic regression analyses were used to derive a 9‐point score for predicting good functional outcome (modified Rankin Scale score 0–2 or return to premorbid modified Rankin Scale score) at 90 days, with sensitivity analyses for prespecified subgroups conducted using bootstrapped random forest regressions. Secondary outcomes included 90‐day functional independence (modified Rankin Scale score 0–2), poor outcome (modified Rankin Scale score 5–6), and 90‐day survival. The score was externally validated with a single‐center cohort (2014–2023). Of the 3231 included patients (n=2499 EVT), a 9‐point score included age, early computed tomography ischemic changes, and stroke severity, with higher points indicating a higher probability of a good functional outcome. The areas under the curve for the primary outcome among EVT and best medical management subgroups were 0.72 (95% CI, 0.70–0.74) and 0.87 (95% CI, 0.84–0.90), respectively, with similar performance in the external validation cohort (area under the curve, 0.71 [95% CI, 0.66–0.76]). There was a significant interaction between the score and EVT for good functional outcome, functional independence, and poor outcome (all Pinteraction<0.001), with greater benefit favoring patients with lower and midrange scores. Conclusions This score is a pragmatic tool that can estimate the probability of a good outcome with EVT in the late window. Registration URL: https://www.Clinicaltrials.gov; Unique identifier: NCT04096248.

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