A comparative study of Sr-loaded nano-textured Ti and TiO2 nanotube implants on osseointegration immediately after tooth extraction in Beagle dogs

Yongfeng Li; Li Tang; Mingming Shen; Zhen Wang; Xiaofeng Huang

doi:10.3389/fmats.2023.1213163

Frontiers in Materials (Jul 2023)

A comparative study of Sr-loaded nano-textured Ti and TiO2 nanotube implants on osseointegration immediately after tooth extraction in Beagle dogs

Yongfeng Li,
Li Tang,
Mingming Shen,
Zhen Wang,
Xiaofeng Huang

Affiliations

Yongfeng Li: Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Li Tang: School of Stomatology, Qingdao University, Qingdao, China
Mingming Shen: Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Zhen Wang: Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Xiaofeng Huang: Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

DOI: https://doi.org/10.3389/fmats.2023.1213163
Journal volume & issue: Vol. 10

Abstract

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Dental implantation, when performed immediately after tooth extraction, simplifies the treatment procedure, resulting in satisfaction for dentists and patients. Dental implants with nanotopography surface modification have been used to promote osseointegration immediately after implantation. We compared two different nanotopography surface implants on the effects of osseointegration immediately after tooth extraction: TiO2 nanotubes (NT-TiO2) fabricated by anodization and Sr-loaded nanotopography Ti (NT-Sr) formed via magnetron sputtering technology. Sr-loaded nanotextured Ti nanotubes (NT-Sr) were fabricated via magnetron sputtering using 99.99% SrTiO3 as the sputtering target. TiO2 nanotubes (NT-TiO2) were fabricated by anodization in 0.5 wt% hydrofluoric acid (HF). After the surface topography, hydrophilicity, chemical components, and interface bonding strength were analyzed, two different nano-topographies were applied for in vivo cellular activity evaluation. Subsequently, the implants with NT-Sr and NT-TiO2 surfaces were inserted into the fresh socket immediately after tooth extraction. Radiological scanning, histological analysis, and biomechanical tests were carried out to investigate implant osseointegration. The results showed that nanotubes with diameters of 15–80 nm were distributed on the NT-TiO2 surface, while the NT-Sr group showed 20–40 nm nanoparticles deposited on the surface. Compared to NT-Sr, the NT-TiO2 surface possessed better hydrophilicity and favorable cellular adhesion and proliferation. The NT-Sr surface possessed greater interfacial bonding strength than the NT-TiO2 group, and greater bone formation, higher bone-to-implant contact (BIC%), and maximum pull-out force were observed in the NT-Sr group. The above results indicated that although the NT-TiO2 surface showed favorable in vitro bioactivity, the NT-Sr surface, with higher interface bonding strength, showed better in vitro osteogenesis, and would be more favorable for immediate implantation.

Published in Frontiers in Materials

ISSN: 2296-8016 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology
Website: https://www.frontiersin.org/journals/materials

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