Frontiers in Pharmacology (Oct 2020)

COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

  • Md. Farhad Hossain,
  • Md. Farhad Hossain,
  • Sharifa Hasana,
  • Abdullah Al Mamun,
  • Abdullah Al Mamun,
  • Md. Sahab Uddin,
  • Md. Sahab Uddin,
  • Mir Imam Ibne Wahed,
  • Sabarni Sarker,
  • Tapan Behl,
  • Irfan Ullah,
  • Yesmin Begum,
  • Israt Jahan Bulbul,
  • Md. Shah Amran,
  • Md. Habibur Rahman,
  • May N. Bin-Jumah,
  • Saad Alkahtani,
  • Shaker A. Mousa,
  • Lotfi Aleya,
  • Mohamed M. Abdel-Daim,
  • Mohamed M. Abdel-Daim

DOI
https://doi.org/10.3389/fphar.2020.563478
Journal volume & issue
Vol. 11

Abstract

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At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).

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