Nature Communications (Jan 2020)
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
- Takanori Furukawa,
- Norman van Rhijn,
- Marcin Fraczek,
- Fabio Gsaller,
- Emma Davies,
- Paul Carr,
- Sara Gago,
- Rachael Fortune-Grant,
- Sayema Rahman,
- Jane Mabey Gilsenan,
- Emma Houlder,
- Caitlin H. Kowalski,
- Shriya Raj,
- Sanjoy Paul,
- Peter Cook,
- Josie E. Parker,
- Steve Kelly,
- Robert A. Cramer,
- Jean-Paul Latgé,
- Scott Moye-Rowley,
- Elaine Bignell,
- Paul Bowyer,
- Michael J. Bromley
Affiliations
- Takanori Furukawa
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Norman van Rhijn
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Marcin Fraczek
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Fabio Gsaller
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Emma Davies
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Paul Carr
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Sara Gago
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Rachael Fortune-Grant
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Sayema Rahman
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Jane Mabey Gilsenan
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Emma Houlder
- Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre
- Caitlin H. Kowalski
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth
- Shriya Raj
- Unité des Aspergillus, Institut Pasteur
- Sanjoy Paul
- Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa
- Peter Cook
- Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre
- Josie E. Parker
- Institute of Life Science, Swansea University Medical School, Swansea University
- Steve Kelly
- Institute of Life Science, Swansea University Medical School, Swansea University
- Robert A. Cramer
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth
- Jean-Paul Latgé
- Unité des Aspergillus, Institut Pasteur
- Scott Moye-Rowley
- Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa
- Elaine Bignell
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Paul Bowyer
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Michael J. Bromley
- Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-019-14191-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary and some salvage therapeutics without affecting pathogenicity.
