Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test

Handong Ouyang; Peizong Wang; Wan Huang; Qiang Li; Bilin Nie; Weian Zeng

doi:10.1155/2015/902914

Pain Research and Management (Jan 2015)

Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test

Handong Ouyang,
Peizong Wang,
Wan Huang,
Qiang Li,
Bilin Nie,
Weian Zeng

Affiliations

Handong Ouyang: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Peizong Wang: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Wan Huang: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Qiang Li: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Bilin Nie: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Weian Zeng: Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

DOI: https://doi.org/10.1155/2015/902914
Journal volume & issue: Vol. 20, no. 6
pp. 321 – 326

Abstract

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BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding and function, acting via the allosteric site on the α2A-adrenergic receptor.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://www.hindawi.com/journals/prm/

About the journal