Nature Communications (Aug 2018)
Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
- Qin Zhang,
- Baoling Bai,
- Xinyu Mei,
- Chunlei Wan,
- Haiyan Cao,
- Dan Li,
- Shan Wang,
- Min Zhang,
- Zhigang Wang,
- Jianxin Wu,
- Hongyan Wang,
- Junsheng Huo,
- Gangqiang Ding,
- Jianyuan Zhao,
- Qiu Xie,
- Li Wang,
- Zhiyong Qiu,
- Shiming Zhao,
- Ting Zhang
Affiliations
- Qin Zhang
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Baoling Bai
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Xinyu Mei
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic, Engineering and Institutes of Biomedical Sciences
- Chunlei Wan
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Haiyan Cao
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Dan Li
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Shan Wang
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Min Zhang
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Zhigang Wang
- Chinese Academy of Medical Sciences & Peking Union Medical College
- Jianxin Wu
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Hongyan Wang
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic, Engineering and Institutes of Biomedical Sciences
- Junsheng Huo
- Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission of the People’s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention
- Gangqiang Ding
- Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission of the People’s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention
- Jianyuan Zhao
- State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University
- Qiu Xie
- Chinese Academy of Medical Sciences & Peking Union Medical College
- Li Wang
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Zhiyong Qiu
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- Shiming Zhao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic, Engineering and Institutes of Biomedical Sciences
- Ting Zhang
- Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics
- DOI
- https://doi.org/10.1038/s41467-018-05451-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.
