共轭亚油酸降脂及分子机理研究进展Progress in fat reduction of conjugated linoleic acid and its molecular mechanism

Abstract

共轭亚油酸是一类具有两个共轭双键的十八碳多不饱和脂肪酸混合物的总称，具有确切的减肥降脂活性与可验证的临床安全性，使其成为国际减肥市场的宠儿。简要回顾了共轭亚油酸减肥降脂的研究成果，并从调控能量代谢、脂代谢、骨骼肌代谢和糖代谢，介导脂肪细胞的分化与凋亡以及调节肠道微生物群6个方面总结了共轭亚油酸减肥降脂的作用机制，同时对其存在问题及发展机会做了分析与讨论。共轭亚油酸作为减肥降脂的天然产物，具有更大、更广阔的发展潜力。 Conjugated linoleic acid, a mixture of eighteen carbon polyunsaturated fatty acid with conjugated double bonds, has many activities in weight loss and fat reduction of the body and verifiable clinical safety, which makes it become one of the hotspots among the international market of losing weight. The research results on weight loss and fat reduction of conjugated linoleic acid was briefly introduced, and the mechanisms on weight loss and fat reduction was summarized from 6 aspects of regulating energy metabolism, lipid metabolism, skeletal muscle metabolism, glucose metabolism, mediating adipocyte differentiation and apoptosis and intestinal microflora, also the existing problems and future opportunity were reviewed and discussed. As a natural product used to lose weight and reduce fat, conjugated linoleic acid has a greater and broader development potential.

Keywords

• 共轭亚油酸；减肥降脂；分子机理
• conjugated linoleic acid; weight loss and fat reduction; molecular mechanism