Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Carla E. Cadena del Castillo; J. Thomas Hannich; Andres Kaech; Hirohisa Chiyoda; Jonathan Brewer; Masamitsu Fukuyama; Nils J. Færgeman; Howard Riezman; Anne Spang

doi:10.1038/s41467-021-24995-9

Nature Communications (Aug 2021)

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Carla E. Cadena del Castillo,
J. Thomas Hannich,
Andres Kaech,
Hirohisa Chiyoda,
Jonathan Brewer,
Masamitsu Fukuyama,
Nils J. Færgeman,
Howard Riezman,
Anne Spang

Affiliations

Carla E. Cadena del Castillo: Biozentrum, University of Basel
J. Thomas Hannich: Department of Biochemistry and NCCR Chemical Biology, University of Geneva
Andres Kaech: Center for Microscopy and Image Analysis, University of Zurich
Hirohisa Chiyoda: Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
Jonathan Brewer: Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark
Masamitsu Fukuyama: Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
Nils J. Færgeman: Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark
Howard Riezman: Department of Biochemistry and NCCR Chemical Biology, University of Geneva
Anne Spang: Biozentrum, University of Basel

DOI: https://doi.org/10.1038/s41467-021-24995-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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