Nature Communications (Sep 2016)
Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene
- Gijs van Ingen,
- Jin Li,
- André Goedegebure,
- Rahul Pandey,
- Yun Rose Li,
- Michael E. March,
- Vincent W. V. Jaddoe,
- Marina Bakay,
- Frank D. Mentch,
- Kelly Thomas,
- Zhi Wei,
- Xiao Chang,
- Heather S. Hain,
- André G. Uitterlinden,
- Henriette A. Moll,
- Cornelia M. van Duijn,
- Fernando Rivadeneira,
- Hein Raat,
- Robert J. Baatenburg de Jong,
- Patrick M. Sleiman,
- Marc P. van der Schroeff,
- Hakon Hakonarson
Affiliations
- Gijs van Ingen
- Department of Otolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam
- Jin Li
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- André Goedegebure
- Department of Otolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam
- Rahul Pandey
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Yun Rose Li
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Michael E. March
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Marina Bakay
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Frank D. Mentch
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Kelly Thomas
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Zhi Wei
- Department of Computer Science, New Jersey Institute of Technology
- Xiao Chang
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Heather S. Hain
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Henriette A. Moll
- Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Fernando Rivadeneira
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Hein Raat
- Department of Public Health, Erasmus MC, University Medical Center Rotterdam
- Robert J. Baatenburg de Jong
- Department of Otolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam
- Patrick M. Sleiman
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Marc P. van der Schroeff
- Department of Otolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam
- Hakon Hakonarson
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/ncomms12792
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 7
Abstract
Acute otitis media (AOM) is an acute infection of middle ear mucosa and among the most common pediatric diseases. Here, the authors performed a genome-wide association study to link a variant in the FNDC1 locus on 6q25.3 and differential methylation status of the FNDC1gene with predisposition to AOM.
