Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

Gongyan Liu; Ce Liu; Yin Zhang; Haitao Sun; Liping Yang; Liya Bai; Shuxia Gao

doi:10.3390/ani13233742

Animals (Dec 2023)

Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

Gongyan Liu,
Ce Liu,
Yin Zhang,
Haitao Sun,
Liping Yang,
Liya Bai,
Shuxia Gao

Affiliations

Gongyan Liu: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Ce Liu: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Yin Zhang: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Haitao Sun: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Liping Yang: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Liya Bai: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China
Shuxia Gao: Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China

DOI: https://doi.org/10.3390/ani13233742
Journal volume & issue: Vol. 13, no. 23
p. 3742

Abstract

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This experiment was conducted to study the effects of different skinning seasons on the fur quality and hair follicle development of Rex rabbits. A total of 80,150-day-old Rex rabbits were slaughtered on 15 July 2022 (summer), 15 October 2022 (autumn), 15 January 2023 (winter), and 15 April 2023 (spring) in Shandong Province (10 males and 10 females in each season). The results show that the skin weight, skin area, skin thickness, and hair follicle density of the Rex rabbits (at 150 days of age) were lower in summer than in winter (p p p p p p Wnt10b, catenin beta 1 (CTNNB1), glycogen synthase kinase 3 beta (GSK3β), insulin like growth factor I (IGF-I), Type I insulin-like growth factor receptor (IGF-IR), and epidermal growth factor (EGF) genes was higher (p dickkopf-1 (DDK1), transforming growth factor beta 1 (TGFβ-1), bone morphogenetic protein 2 (BMP2), and bone morphogenetic protein 4 (BMP4) genes was lower than in summer (p p p p < 0.05). These results show that the skinning season can affect the production performance and hair follicle development of Rex rabbits. Compared with other seasons, the quality of skin from rabbits slaughtered in winter is better. Seasons may regulate hair follicle development via the Wnt10b/β-catenin, TGFβ-BMP, IGF1, and EGF signaling pathways in Rex rabbits.

Published in Animals

ISSN: 2076-2615 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine; Science: Zoology
Website: http://www.mdpi.com/journal/animals/

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