PLoS ONE (Jan 2020)

Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy.

  • Dured Dardari,
  • Georges Ha Van,
  • Jocelyne M'Bemba,
  • Francois-Xavier Laborne,
  • Olivier Bourron,
  • Jean Michel Davaine,
  • Franck Phan,
  • Fabienne Foufelle,
  • Frédéric Jaisser,
  • Alfred Penfornis,
  • Agnes Hartemann

DOI
https://doi.org/10.1371/journal.pone.0233168
Journal volume & issue
Vol. 15, no. 5
p. e0233168

Abstract

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OBJECTIVE:Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS:HbA1c levels and other relevant data were extracted from medical databases of 44 cases of acute Charcot neuroarthropathy. RESULTS:HbA1c levels significantly declined from 8.25% (67mmol/mol) [7.1%-9.4%](54-79mmol/mol), at -6 months (M-6), to 7.40%(54mmol/mol) [6.70%-8.03%] (50-64 mmol/mol) during the six months preceding the diagnosis of Charcot neuroarthropathy (P <0.001). CONCLUSIONS:HbA1c levels significantly declined during the six months preceding the onset of Charcot neuroarthropathy. This decline seems to be a associated factor with the appearance of an active phase of Charcot neuroarthropathy in poorly controlled patients with diabetic sensitive neuropathy.