Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1

Rina Hirano; Haruhiko Ehara; Tomoya Kujirai; Tamami Uejima; Yoshimasa Takizawa; Shun-ichi Sekine; Hitoshi Kurumizaka

doi:10.1038/s41467-022-35003-z

Nature Communications (Nov 2022)

Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1

Rina Hirano,
Haruhiko Ehara,
Tomoya Kujirai,
Tamami Uejima,
Yoshimasa Takizawa,
Shun-ichi Sekine,
Hitoshi Kurumizaka

Affiliations

Rina Hirano: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Haruhiko Ehara: RIKEN Center for Biosystems Dynamics Research
Tomoya Kujirai: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Tamami Uejima: RIKEN Center for Biosystems Dynamics Research
Yoshimasa Takizawa: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Shun-ichi Sekine: RIKEN Center for Biosystems Dynamics Research
Hitoshi Kurumizaka: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-35003-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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