Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Abstract

Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing paracrine Wnt/β-catenin signaling.