Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter; Hannah C. Leeson; Mohammed R. Shaker; Ernst J. Wolvetang; Lata Vadlamudi

Stem Cell Research (Apr 2022)

Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter,
Hannah C. Leeson,
Mohammed R. Shaker,
Ernst J. Wolvetang,
Lata Vadlamudi

Affiliations

Zoe L. Hunter: The University of Queensland, Australian Institute for Bioengineering & Nanotechnology (AIBN), St. Lucia, Brisbane, QLD 4072, Australia
Hannah C. Leeson: The University of Queensland, Australian Institute for Bioengineering & Nanotechnology (AIBN), St. Lucia, Brisbane, QLD 4072, Australia
Mohammed R. Shaker: The University of Queensland, Australian Institute for Bioengineering & Nanotechnology (AIBN), St. Lucia, Brisbane, QLD 4072, Australia
Ernst J. Wolvetang: The University of Queensland, Australian Institute for Bioengineering & Nanotechnology (AIBN), St. Lucia, Brisbane, QLD 4072, Australia; Corresponding author.
Lata Vadlamudi: The University of Queensland, UQ Centre for Clinical Research, Herston Brisbane, QLD 4029, Australia; Department of Neurology, Royal Brisbane and Women’s Hospital, Herston Brisbane, QLD 4029, Australia

Journal volume & issue: Vol. 60
p. 102673

Abstract

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In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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