Nature Communications (May 2018)

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

  • Anita Sarkar,
  • Shridhar Bale,
  • Anna-Janina Behrens,
  • Sonu Kumar,
  • Shailendra Kumar Sharma,
  • Natalia de Val,
  • Jesper Pallesen,
  • Adriana Irimia,
  • Devan C. Diwanji,
  • Robyn L. Stanfield,
  • Andrew B. Ward,
  • Max Crispin,
  • Richard T. Wyatt,
  • Ian A. Wilson

DOI
https://doi.org/10.1038/s41467-018-04272-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architecture and glycosylation of the native cleaved trimer.