Фармакокинетика и Фармакодинамика (Mar 2018)

Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma

  • M. A. Yarkova,
  • A. A. Litvin,
  • G. B. Kolyvanov,
  • V. P. Zherdev,
  • S. B. Seredenin,
  • V. I. Gegechkori

DOI
https://doi.org/10.24411/25877836-2018-10014.
Journal volume & issue
Vol. 0, no. 2
pp. 52 – 58

Abstract

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Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLevated pLus maze” were evaLuated. A vaLue of GML-1 anxioLytic effect does not correLate to concentration in the rat bLood pLasma.

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