Determination of clopidogrel using square wave voltammetry at a gold electrode

Abstract

The determination of clopidogrel, an antiplatelet agent, was performed at a gold electrode in pH 3.7 acetate buffer using cyclic voltammetry (CV) and square wave voltammetry (SWV). Each voltammogram is characterized by the well defined peak at approximately 1.0 V. The current of anodic stripping peak exhibits linear dependence on the clopidogrel concentration in a range from 317.89 mg cm-3 to 935.16 mg cm-3. The obtained linearity was applied to determine clopidogrel amount in the tablet form of pharmaceutical preparation (Plavix®). The results were compared to the UV spectrophotometric and HPLC method. [Projekat Ministarstva nauke republike Srbije, br. ON172013]

Keywords

• cyclic voltammetry
• acetate buffer
• tablet
• UV
• HPLC