Proceedings (Aug 2019)
Hydrophobic Waters in Bromodomains
- Serena G. Piticchio,
- Miriam Martínez-Cartró,
- Salvatore Scaffidi,
- Sergio Rodríguez-Arévalo,
- Andrea Bagán,
- Ainoa Sánchez-Arfelis,
- Carmen Escolano,
- Carles Galdeano,
- Xavier Barril
Affiliations
- Serena G. Piticchio
- Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
- Miriam Martínez-Cartró
- Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
- Salvatore Scaffidi
- Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
- Sergio Rodríguez-Arévalo
- Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
- Andrea Bagán
- Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
- Ainoa Sánchez-Arfelis
- Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
- Carmen Escolano
- Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
- Carles Galdeano
- Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
- Xavier Barril
- Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
- DOI
- https://doi.org/10.3390/proceedings2019022080
- Journal volume & issue
-
Vol. 22,
no. 1
p. 80
Abstract
Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug [...]
Keywords
- bromodomains
- BRD4
- structural water molecules
- fragment-based drug design
- medicinal chemistry
- crystallography
- drug discovery
