VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

Steve Cornick; Manish Kumar; France Moreau; Herbert Gaisano; Kris Chadee

doi:10.1038/s41467-019-11811-8

Nature Communications (Sep 2019)

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

Steve Cornick,
Manish Kumar,
France Moreau,
Herbert Gaisano,
Kris Chadee

Affiliations

Steve Cornick: Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary
Manish Kumar: Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary
France Moreau: Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary
Herbert Gaisano: Departments of Medicine and Physiology, University of Toronto
Kris Chadee: Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary

DOI: https://doi.org/10.1038/s41467-019-11811-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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