Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

Abdulrahim A. Sajini; Nila Roy Choudhury; Rebecca E. Wagner; Susanne Bornelöv; Tommaso Selmi; Christos Spanos; Sabine Dietmann; Juri Rappsilber; Gracjan Michlewski; Michaela Frye

doi:10.1038/s41467-019-10020-7

Nature Communications (Jun 2019)

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

Abdulrahim A. Sajini,
Nila Roy Choudhury,
Rebecca E. Wagner,
Susanne Bornelöv,
Tommaso Selmi,
Christos Spanos,
Sabine Dietmann,
Juri Rappsilber,
Gracjan Michlewski,
Michaela Frye

Affiliations

Abdulrahim A. Sajini: Department of Genetics, University of Cambridge
Nila Roy Choudhury: Division of Infection and Pathway Medicine, University of Edinburgh
Rebecca E. Wagner: Department of Genetics, University of Cambridge
Susanne Bornelöv: Wellcome MRC Cambridge Stem Cell Institute
Tommaso Selmi: Department of Genetics, University of Cambridge
Christos Spanos: Wellcome Centre for Cell Biology, University of Edinburgh
Sabine Dietmann: Wellcome MRC Cambridge Stem Cell Institute
Juri Rappsilber: Wellcome Centre for Cell Biology, University of Edinburgh
Gracjan Michlewski: Division of Infection and Pathway Medicine, University of Edinburgh
Michaela Frye: Department of Genetics, University of Cambridge

DOI: https://doi.org/10.1038/s41467-019-10020-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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RNA modifications, including 5-methylcytosines, are known regulators of RNA metabolism affecting protein-RNA binding. Here, the authors reveal the role of m5C in the biogenesis of the non-coding vault-derived small RNAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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