Nature Communications (Apr 2021)
Genomic profile of advanced breast cancer in circulating tumour DNA
- Belinda Kingston,
- Rosalind J. Cutts,
- Hannah Bye,
- Matthew Beaney,
- Giselle Walsh-Crestani,
- Sarah Hrebien,
- Claire Swift,
- Lucy S. Kilburn,
- Sarah Kernaghan,
- Laura Moretti,
- Katie Wilkinson,
- Andrew M. Wardley,
- Iain R. Macpherson,
- Richard D. Baird,
- Rebecca Roylance,
- Jorge S. Reis-Filho,
- Michael Hubank,
- Iris Faull,
- Kimberly C. Banks,
- Richard B. Lanman,
- Isaac Garcia-Murillas,
- Judith M. Bliss,
- Alistair Ring,
- Nicholas C. Turner
Affiliations
- Belinda Kingston
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Rosalind J. Cutts
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Hannah Bye
- Centre for Molecular Pathology, Royal Marsden Hospital
- Matthew Beaney
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Giselle Walsh-Crestani
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Sarah Hrebien
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Claire Swift
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Lucy S. Kilburn
- ICR-CTSU, The Institute of Cancer Research
- Sarah Kernaghan
- ICR-CTSU, The Institute of Cancer Research
- Laura Moretti
- ICR-CTSU, The Institute of Cancer Research
- Katie Wilkinson
- ICR-CTSU, The Institute of Cancer Research
- Andrew M. Wardley
- NIHR Manchester Clinical Research Facility at The Christie, Manchester Academic Health Science Centre & Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine & Health, University of Manchester
- Iain R. Macpherson
- The Beatson West of Scotland Cancer Centre
- Richard D. Baird
- Cancer Research UK Cambridge Centre
- Rebecca Roylance
- University College London Hospitals NHS Foundation Trust
- Jorge S. Reis-Filho
- Memorial Sloan Kettering Cancer Centre
- Michael Hubank
- Centre for Molecular Pathology, Royal Marsden Hospital
- Iris Faull
- Guardant Health, Inc.
- Kimberly C. Banks
- Guardant Health, Inc.
- Richard B. Lanman
- Guardant Health, Inc.
- Isaac Garcia-Murillas
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Judith M. Bliss
- ICR-CTSU, The Institute of Cancer Research
- Alistair Ring
- Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital
- Nicholas C. Turner
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-021-22605-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Circulating tumour DNA can provide useful information on disease burden. Here, the authors analysed circulating tumour DNA from 800 patients from a breast cancer clinical trial and investigate the subclonal nature of the disease, and identify DNA mutations associated with resistance and poor survival.
