Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis

Antonio P. A. Ferreira; Alessandra Casamento; Sara Carrillo Roas; Els F. Halff; James Panambalana; Shaan Subramaniam; Kira Schützenhofer; Laura Chan Wah Hak; Kieran McGourty; Konstantinos Thalassinos; Josef T. Kittler; Denis Martinvalet; Emmanuel Boucrot

doi:10.1038/s41467-021-22603-4

Nature Communications (Apr 2021)

Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis

Antonio P. A. Ferreira,
Alessandra Casamento,
Sara Carrillo Roas,
Els F. Halff,
James Panambalana,
Shaan Subramaniam,
Kira Schützenhofer,
Laura Chan Wah Hak,
Kieran McGourty,
Konstantinos Thalassinos,
Josef T. Kittler,
Denis Martinvalet,
Emmanuel Boucrot

Affiliations

Antonio P. A. Ferreira: Institute of Structural and Molecular Biology, University College London
Alessandra Casamento: Institute of Structural and Molecular Biology, University College London
Sara Carrillo Roas: Institute of Structural and Molecular Biology, University College London
Els F. Halff: Department of Neuroscience, Physiology, and Pharmacology, University College London
James Panambalana: Institute of Structural and Molecular Biology, University College London
Shaan Subramaniam: Institute of Structural and Molecular Biology, University College London
Kira Schützenhofer: Institute of Structural and Molecular Biology, University College London
Laura Chan Wah Hak: Institute of Structural and Molecular Biology, University College London
Kieran McGourty: Institute of Structural and Molecular Biology, University College London
Konstantinos Thalassinos: Institute of Structural and Molecular Biology, University College London
Josef T. Kittler: Department of Neuroscience, Physiology, and Pharmacology, University College London
Denis Martinvalet: Department of Biochemistry, University of Padova
Emmanuel Boucrot: Institute of Structural and Molecular Biology, University College London

DOI: https://doi.org/10.1038/s41467-021-22603-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Here, the authors show that Cdk5 and GSK3β are negative regulators of fast Endophilin-mediated endocytosis (FEME).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal