Nature Communications (Nov 2022)
Decoding molecular programs in melanoma brain metastases
- Josefine Radke,
- Elisa Schumann,
- Julia Onken,
- Randi Koll,
- Güliz Acker,
- Bohdan Bodnar,
- Carolin Senger,
- Sascha Tierling,
- Markus Möbs,
- Peter Vajkoczy,
- Anna Vidal,
- Sandra Högler,
- Petra Kodajova,
- Dana Westphal,
- Friedegund Meier,
- Frank Heppner,
- Susanne Kreuzer-Redmer,
- Florian Grebien,
- Karsten Jürchott,
- Torben Redmer
Affiliations
- Josefine Radke
- Department of Pathology, University Medicine Greifswald
- Elisa Schumann
- German Cancer Consortium (DKTK), Partner Site Berlin, CCCC (Campus Mitte)
- Julia Onken
- German Cancer Consortium (DKTK), Partner Site Berlin, CCCC (Campus Mitte)
- Randi Koll
- German Cancer Consortium (DKTK), Partner Site Berlin, CCCC (Campus Mitte)
- Güliz Acker
- Berlin Institute of Health (BIH)
- Bohdan Bodnar
- Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Carolin Senger
- Charité CyberKnife Center, Department of Radiation Oncology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Sascha Tierling
- Department of Genetics/Epigenetics, Faculty NT, Saarland University
- Markus Möbs
- Department of Pathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Peter Vajkoczy
- Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Anna Vidal
- Institute for Medical Biochemistry, University of Veterinary Medicine Vienna
- Sandra Högler
- Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna
- Petra Kodajova
- Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna
- Dana Westphal
- Department of Dermatology, University Hospital Carl Gustav Carus at TU Dresden
- Friedegund Meier
- Department of Dermatology, University Hospital Carl Gustav Carus at TU Dresden
- Frank Heppner
- Berlin Institute of Health (BIH)
- Susanne Kreuzer-Redmer
- Nutrigenomics Unit, Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine Vienna
- Florian Grebien
- Institute for Medical Biochemistry, University of Veterinary Medicine Vienna
- Karsten Jürchott
- Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Center for Regenerative Therapies (BCRT)
- Torben Redmer
- Institute for Medical Biochemistry, University of Veterinary Medicine Vienna
- DOI
- https://doi.org/10.1038/s41467-022-34899-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 24
Abstract
Melanoma brain metastases (MBM) show heterogeneous therapeutic response determined by incompletely understood mechanisms. Here, the authors use a multi-OMICS approach and targeted sequencing (TargetSeq) to decipher programs that may define molecular subsets of MBM and their response to therapy.
