Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum

Joseph W. Saelens; Jens E. V. Petersen; Elizabeth Freedman; Robert C. Moseley; Drissa Konaté; Seidina A. S. Diakité; Karim Traoré; Natalie Vance; Rick M. Fairhurst; Mahamadou Diakité; Steven B. Haase; Steve M. Taylor

doi:10.1128/mSphere.00755-21

mSphere (Oct 2021)

Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum

Joseph W. Saelens,
Jens E. V. Petersen,
Elizabeth Freedman,
Robert C. Moseley,
Drissa Konaté,
Seidina A. S. Diakité,
Karim Traoré,
Natalie Vance,
Rick M. Fairhurst,
Mahamadou Diakité,
Steven B. Haase,
Steve M. Taylor

Affiliations

Joseph W. Saelens: Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Jens E. V. Petersen: Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Elizabeth Freedman: Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Robert C. Moseley: Department of Biology, Duke University, Durham, North Carolina, USA
Drissa Konaté: Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Seidina A. S. Diakité: Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Karim Traoré: Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Natalie Vance: Duke Global Health Institute, Duke University, Durham, North Carolina, USA
Rick M. Fairhurst: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Mahamadou Diakité: Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Steven B. Haase: Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Steve M. Taylor: ORCiD; Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA

DOI: https://doi.org/10.1128/mSphere.00755-21
Journal volume & issue: Vol. 6, no. 5

Abstract

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Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we used transcriptome sequencing (RNA-seq) to measure the impact of HbAS on the blood-stage transcriptome of Plasmodium falciparumin vitroin vivo

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal