Fertility and Pregnancy-Related Issues in Young  Carriers With Breast Cancer

Isotta Martha Magaton; Luca Arecco; Elene Mariamidze; Kristina Jankovic; Mihaela Stana; Giulia Buzzatti; Lucia Trevisan; Graziana Scavone; Silvia Ottonello; Piero Fregatti; Claudia Massarotti; Michael von Wolff; Matteo Lambertini

doi:10.1177/11782234241261429

Breast Cancer: Basic and Clinical Research (Jun 2024)

Fertility and Pregnancy-Related Issues in Young Carriers With Breast Cancer

Isotta Martha Magaton,
Luca Arecco,
Elene Mariamidze,
Kristina Jankovic,
Mihaela Stana,
Giulia Buzzatti,
Lucia Trevisan,
Graziana Scavone,
Silvia Ottonello,
Piero Fregatti,
Claudia Massarotti,
Michael von Wolff,
Matteo Lambertini

Affiliations

Isotta Martha Magaton: Department of Medical Oncology, U.O.C. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Luca Arecco: Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genoa, Genoa, Italy
Elene Mariamidze: Department of Medical Oncology & Hematology, Todua Clinic, Tbilisi, Georgien
Kristina Jankovic: Department of Medical Oncology, University Clinic Center Nis, Nis, Serbia
Mihaela Stana: Department of Medical Oncology, Elysee Hospital, Alba Iulia, Romania
Giulia Buzzatti: Department of Medical Oncology, Unit of Hereditary Cancer, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Lucia Trevisan: Department of Medical Oncology, Unit of Hereditary Cancer, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Graziana Scavone: Department of Medical Oncology, U.O.C. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Silvia Ottonello: Departent of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy
Piero Fregatti: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, Genoa, Italy
Claudia Massarotti: Academic Unit of Obstetrics and Gynecology, Maternal-Child Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Michael von Wolff: Division of Gynaecological Endocrinology and Reproductive Medicine, University Women’s Hospital, Inselspital, Bern, Switzerland
Matteo Lambertini: Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genoa, Genoa, Italy

DOI: https://doi.org/10.1177/11782234241261429
Journal volume & issue: Vol. 18

Abstract

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Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 ( BRCA1 ) or BReast CAncer 2 ( BRCA2 ) genes. Preclinical and clinical studies showed a potential negative effect of germline BRCA 1/2 (g BRCA1/2 ) PVs on ovarian reserve and reproductive potential, even before starting anticancer therapies. The aim of this article is to summarize the current literature on the fertility potential of young g BRCA1/2 PVs carriers with breast cancer and the risk of gonadotoxicity associated with anticancer treatments. Moreover, we describe the available evidence on the efficacy of fertility preservation techniques in young g BRCA1/2 PVs carriers and the safety data on having a pregnancy after breast cancer treatment.

Published in Breast Cancer: Basic and Clinical Research

ISSN: 1178-2234 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://journals.sagepub.com/home/bcb

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