Neutrophil swarming delays the growth of clusters of pathogenic fungi

Alex Hopke; Allison Scherer; Samantha Kreuzburg; Michael S. Abers; Christa S. Zerbe; Mary C. Dinauer; Michael K. Mansour; Daniel Irimia

doi:10.1038/s41467-020-15834-4

Nature Communications (Apr 2020)

Neutrophil swarming delays the growth of clusters of pathogenic fungi

Alex Hopke,
Allison Scherer,
Samantha Kreuzburg,
Michael S. Abers,
Christa S. Zerbe,
Mary C. Dinauer,
Michael K. Mansour,
Daniel Irimia

Affiliations

Alex Hopke: BioMEMS Resource Center, Massachusetts General Hospital
Allison Scherer: Harvard Medical School
Samantha Kreuzburg: Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Michael S. Abers: Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Christa S. Zerbe: Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Mary C. Dinauer: Departments of Pediatrics and of Pathology and Immunology, Washington University School of Medicine in St. Louis
Michael K. Mansour: Harvard Medical School
Daniel Irimia: BioMEMS Resource Center, Massachusetts General Hospital

DOI: https://doi.org/10.1038/s41467-020-15834-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Neutrophils employ several mechanisms to control the growth of fungi, including enzymes, reactive oxygen species, extracellular traps, and formation of “swarms”. Here, Hopke et al. study how the different mechanisms work together, using an in vitro assay with human neutrophils and clusters of live Candida cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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