Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing

Wade F. Zeno; Upayan Baul; Wilton T. Snead; Andre C. M. DeGroot; Liping Wang; Eileen M. Lafer; D. Thirumalai; Jeanne C. Stachowiak

doi:10.1038/s41467-018-06532-3

Nature Communications (Oct 2018)

Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing

Wade F. Zeno,
Upayan Baul,
Wilton T. Snead,
Andre C. M. DeGroot,
Liping Wang,
Eileen M. Lafer,
D. Thirumalai,
Jeanne C. Stachowiak

Affiliations

Wade F. Zeno: Department of Biomedical Engineering, The University of Texas at Austin
Upayan Baul: Department of Chemistry, The University of Texas at Austin
Wilton T. Snead: Department of Biomedical Engineering, The University of Texas at Austin
Andre C. M. DeGroot: Department of Biomedical Engineering, The University of Texas at Austin
Liping Wang: Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio
Eileen M. Lafer: Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio
D. Thirumalai: Department of Chemistry, The University of Texas at Austin
Jeanne C. Stachowiak: Department of Biomedical Engineering, The University of Texas at Austin

DOI: https://doi.org/10.1038/s41467-018-06532-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Many proteins which sense membrane curvature contain intrinsically disordered domains. Here the authors use Monte Carlo simulations combined with experimental approaches and report that disordered domains are potent sensors of membrane curvature.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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