Nature Communications (Sep 2020)

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

  • John S. O’ Neill,
  • Nathaniel P. Hoyle,
  • J. Brian Robertson,
  • Rachel S. Edgar,
  • Andrew D. Beale,
  • Sew Y. Peak-Chew,
  • Jason Day,
  • Ana S. H. Costa,
  • Christian Frezza,
  • Helen C. Causton

DOI
https://doi.org/10.1038/s41467-020-18330-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Yeast exhibit oscillations that share features with circadian rhythms. The authors show that bioenergetic constraints promote oscillatory behaviour: resources are stored until supplies can support translational bursting, this is licensed by ion transport and release from membrane-less compartments.