Impact of different energy sources on coagulation biomarkers and silent cerebral events in balloon-based ablation for atrial fibrillation

Masayuki Koshikawa, MD, PhD; Masahide Harada, MD, PhD; Yoshihiro Nomura, MD; Asuka Nishimura, MD; Yuji Motoike, MD, PhD; Eiichi Watanabe, MD, PhD; Yukio Ozaki, MD, PhD; Hideo Izawa, MD, PhD

Heart Rhythm O2 (Aug 2024)

Impact of different energy sources on coagulation biomarkers and silent cerebral events in balloon-based ablation for atrial fibrillation

Masayuki Koshikawa, MD, PhD,
Masahide Harada, MD, PhD,
Yoshihiro Nomura, MD,
Asuka Nishimura, MD,
Yuji Motoike, MD, PhD,
Eiichi Watanabe, MD, PhD,
Yukio Ozaki, MD, PhD,
Hideo Izawa, MD, PhD

Affiliations

Masayuki Koshikawa, MD, PhD: Department of Cardiology, Fujita Health University, Toyoake, Japan
Masahide Harada, MD, PhD: Department of Cardiology, Fujita Health University, Toyoake, Japan; Address reprint requests and correspondence: Dr Masahide Harada, Department of Cardiology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 4701192, Japan.
Yoshihiro Nomura, MD: Department of Cardiology, Fujita Health University, Toyoake, Japan
Asuka Nishimura, MD: Department of Cardiology, Fujita Health University, Toyoake, Japan
Yuji Motoike, MD, PhD: Department of Cardiology, Fujita Health University, Toyoake, Japan
Eiichi Watanabe, MD, PhD: Department of Cardiology, Bantane Hospital, Fujita Health University, Nagoya, Japan
Yukio Ozaki, MD, PhD: Department of Cardiology, Okazaki Medical Center, Fujita Health University, Okazaki, Japan
Hideo Izawa, MD, PhD: Department of Cardiology, Fujita Health University, Toyoake, Japan

Journal volume & issue: Vol. 5, no. 8
pp. 520 – 528

Abstract

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Background: Different energy sources of balloon-based ablation for pulmonary vein isolation cause different kinds of endothelial damage and coagulation responses associated with thromboembolic risk. Objectives: The study sought to compare the impact of different balloon-based ablation, cryoballoon ablation (CBA) and laser balloon ablation (LBA), on coagulation/fibrinolysis biomarkers and silent cerebral events (SCEs) in paroxysmal atrial fibrillation. Methods: Paroxysmal atrial fibrillation patients who underwent pulmonary vein isolation using either CBA (n = 52) or LBA (n = 53) without radiofrequency touch-up ablation were eligible. Time course (day 0 [before ablation], day 1, day 2, and day 28) of myocardial enzymes and inflammatory and coagulation/fibrinolysis biomarkers was evaluated during the perioperative period. Brain magnetic resonance imaging was performed within 2 days after the procedure to evaluate SCEs. Results: There was no difference in patient characteristics between CBA and LBA.CBA had greater myocardial injury (troponin I and creatine kinase-MB) and lower inflammatory reaction (white blood cell count and neutrophil/lymphocyte ratio) than LBA. The coagulation biomarkers maximally increased by day 2 and then decreased in both groups. In day 28, the serum prothrombin fragment 1+2 and D-dimer levels in LBA were significantly higher than the values in CBA. The fibrinolysis biomarker (plasmin-α2 plasmin inhibitor complex) did not increase after the procedure in either group. The incidence of SCEs was comparable between CBA and LBA (11% vs 15%; P = .591). No thromboembolic event was observed. Conclusion: CBA and LBA had different effects on myocardial injury, inflammatory reaction, and coagulation activity but did not affect the incidence of thromboembolic events. LBA had significantly higher coagulation activity in day 28 and may require more careful postprocedural anticoagulation than CBA.

Published in Heart Rhythm O2

ISSN: 2666-5018 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/heart-rhythm-o2

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