Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

Jianqin Lu; Xiangsheng Liu; Yu-Pei Liao; Felix Salazar; Bingbing Sun; Wen Jiang; Chong Hyun Chang; Jinhong Jiang; Xiang Wang; Anna M. Wu; Huan Meng; Andre E. Nel

doi:10.1038/s41467-017-01651-9

Nature Communications (Nov 2017)

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

Jianqin Lu,
Xiangsheng Liu,
Yu-Pei Liao,
Felix Salazar,
Bingbing Sun,
Wen Jiang,
Chong Hyun Chang,
Jinhong Jiang,
Xiang Wang,
Anna M. Wu,
Huan Meng,
Andre E. Nel

Affiliations

Jianqin Lu: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California
Xiangsheng Liu: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California
Yu-Pei Liao: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California
Felix Salazar: Department of Molecular and Medical Pharmacology Crump Institute for Molecular Imaging, David Geffen School of Medicine
Bingbing Sun: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California
Wen Jiang: Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California
Chong Hyun Chang: Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California
Jinhong Jiang: Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California
Xiang Wang: Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California
Anna M. Wu: Department of Molecular and Medical Pharmacology Crump Institute for Molecular Imaging, David Geffen School of Medicine
Huan Meng: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California
Andre E. Nel: Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-017-01651-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Pancreatic cancer remains difficult to treat mainly due to the drug delivery challenges posed by a strong stromal component. Here the authors develop nanocarriers that improve drug delivery efficiency and engage the host immune system against the tumor resulting in reduction of tumor growth and metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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