Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms

Abstract

Therapy-related myeloid neoplasms (t-MN) are a growing concern due to the continued use of cytotoxic therapies to treat malignancies. Cytotoxic therapies have been shown to drive therapy-induced senescence in normal tissues, including in the bone marrow microenvironment (BMME), which plays a crucial role in supporting normal hematopoiesis. This review examines recent work that focuses on the contribution of BMME senescence to t-MN pathogenesis, as well as offers a perspective on potential opportunities for therapeutic intervention.

Keywords

• Senescence
• Myeloid neoplasm
• Clonal hematopoiesis
• Bone marrow microenvironment
• Bone marrow stromal cell
• Senolytics