The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

Salvatore Incontro; Javier Díaz-Alonso; Jillian Iafrati; Marta Vieira; Cedric S. Asensio; Vikaas S. Sohal; Katherine W. Roche; Kevin J. Bender; Roger A. Nicoll

doi:10.1038/s41467-018-04439-7

Nature Communications (May 2018)

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

Salvatore Incontro,
Javier Díaz-Alonso,
Jillian Iafrati,
Marta Vieira,
Cedric S. Asensio,
Vikaas S. Sohal,
Katherine W. Roche,
Kevin J. Bender,
Roger A. Nicoll

Affiliations

Salvatore Incontro: Department of Cellular and Molecular Pharmacology, University of California, San Francisco
Javier Díaz-Alonso: Department of Cellular and Molecular Pharmacology, University of California, San Francisco
Jillian Iafrati: Department of Psychiatry, University of California, San Francisco
Marta Vieira: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Cedric S. Asensio: Department of Biological Sciences, University of Denver
Vikaas S. Sohal: Department of Psychiatry, University of California, San Francisco
Katherine W. Roche: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Kevin J. Bender: Department of Neurology, University of California, San Francisco
Roger A. Nicoll: Department of Cellular and Molecular Pharmacology, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-018-04439-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 21

Abstract

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Calcium-calmodulin-dependent protein kinase II (CaMKII) is well known for its roles in synaptic plasticity. Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity and basal AMPA receptor-mediated transmission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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