Fullerene [60] encapsulated water-soluble supramolecular cage for prevention of oxidative stress-induced myocardial injury

Guanzhao Zhang; Hui Fang; Shuting Chang; Renzeng Chen; Lanlan Li; Danbo Wang; Yamei Liu; Ruyi Sun; Yingjie Zhao; Bo Li

Materials Today Bio (Aug 2023)

Fullerene [60] encapsulated water-soluble supramolecular cage for prevention of oxidative stress-induced myocardial injury

Guanzhao Zhang,
Hui Fang,
Shuting Chang,
Renzeng Chen,
Lanlan Li,
Danbo Wang,
Yamei Liu,
Ruyi Sun,
Yingjie Zhao,
Bo Li

Affiliations

Guanzhao Zhang: Department of Cardiology, Binzhou Medical University, Zibo Central Hospital, NO.10, South Shanghai Road, Zibo, 255000, China
Hui Fang: College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China
Shuting Chang: Weifang Medical University, NO.7166, Baotong West Street, Weifang, 261053, China
Renzeng Chen: College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China
Lanlan Li: Center of Translational Medicine, Zibo Central Hospital, NO.10, South Shanghai Road, Zibo, 255000, China
Danbo Wang: College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China
Yamei Liu: School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, China
Ruyi Sun: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China; Corresponding author.
Yingjie Zhao: College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China; Corresponding author.
Bo Li: Department of Cardiology, Binzhou Medical University, Zibo Central Hospital, NO.10, South Shanghai Road, Zibo, 255000, China; Corresponding author.

Journal volume & issue: Vol. 21
p. 100693

Abstract

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A water-soluble cube-like supramolecular cage was constructed by an engagement of six molecules through a hydrophobic effect in the water. The obtained cage could perfectly encapsulate one fullerene C60 molecule inside of the cavity and significantly improve the water-solubility of the C60 without changing the original structure. The water-soluble complex was further applied to reduce the reactive oxygen species (R.O.S.) in cardiomyocytes (FMC84) through Akt/Nrf2/HO-1 pathway. Furthermore, in the mouse model of myocardial ischemia-reperfusion injury, the application of C60 was found to be effective in reducing myocardial injury and improving cardiac function. It also reduced the levels of R.O.S. in myocardial tissue, inhibited myocardial apoptosis, and mitigated myocardial inflammatory responses. The present study provides a new guideline for constructing water-soluble C60 and verifies the important role of C60 in preventing oxidative stress-related cardiovascular disease injury.

Published in Materials Today Bio

ISSN: 2590-0064 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/materials-today-bio

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