Histologic Assessment of Thromboemboli Due to Plaque Rupture, Plaque Erosion, or COVID-19 Microthrombi

Takao Konishi, MD; Kenji Kawai, MD; Rika Kawakami, MD; Saikat Kumar B. Ghosh, PHD; Aimee E. Vozenilek, PHD; Arielle Bellissard, MD; Weili Xu, MD; Renu Virmani, MD; Aloke V. Finn, MD

JACC: Case Reports (May 2023)

Histologic Assessment of Thromboemboli Due to Plaque Rupture, Plaque Erosion, or COVID-19 Microthrombi

Takao Konishi, MD,
Kenji Kawai, MD,
Rika Kawakami, MD,
Saikat Kumar B. Ghosh, PHD,
Aimee E. Vozenilek, PHD,
Arielle Bellissard, MD,
Weili Xu, MD,
Renu Virmani, MD,
Aloke V. Finn, MD

Affiliations

Takao Konishi, MD: CVPath Institute, Gaithersburg, Maryland, USA
Kenji Kawai, MD: CVPath Institute, Gaithersburg, Maryland, USA
Rika Kawakami, MD: CVPath Institute, Gaithersburg, Maryland, USA
Saikat Kumar B. Ghosh, PHD: CVPath Institute, Gaithersburg, Maryland, USA
Aimee E. Vozenilek, PHD: CVPath Institute, Gaithersburg, Maryland, USA
Arielle Bellissard, MD: CVPath Institute, Gaithersburg, Maryland, USA
Weili Xu, MD: CVPath Institute, Gaithersburg, Maryland, USA
Renu Virmani, MD: CVPath Institute, Gaithersburg, Maryland, USA
Aloke V. Finn, MD: CVPath Institute, Gaithersburg, Maryland, USA; University of Maryland, School of Medicine, Baltimore, Maryland, USA; Address for correspondence: Dr Aloke V. Finn, CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, Maryland 20878, USA.

Journal volume & issue: Vol. 14
p. 101826

Abstract

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Plaque rupture, plaque erosion, and COVID-19 infection can cause acute coronary syndromes (ACS). We illustrate case examples demonstrating the distinctive and characteristic pathologic findings underlying each of these various causes of acute myocardial infarction. A deeper understanding of the pathophysiology of ACS is necessary for the development of newer agents and techniques to improve outcomes after ACS. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

About the journal

Abstract

Keywords