1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins

• Per thor Straten,
• Ralf Wagner,
• Peter Holst,
• Louise Turner,
• Amaia V Bermejo,
• Isabella Skandorff,
• Lasse Neukirch,
• Jasmin Gille,
• Frederik O Bagger,
• Karen N Nielsen,
• Joana Daradoumis,
• Charlie R Ince,
• Lara Duvnjak,
• Mikkel D Müller,
• Silke Schrödel,
• Kaare Grunddal,
• Kristoffer Staahl Rohrberg,
• Christian Thirion,
• Anne-Marie Andersson,
• Emeline Ragonnaud

Affiliations

Per thor Straten

1National Center for Cancer Immune Therapy (CCIT-DK), Herlev, Denmark

Ralf Wagner

2University of Regensburg, Regensburg, Bayern, Germany

Peter Holst

1HERVOLUTION Therapeutics, COPENHAGEN, Greater Copenhagen, Denmark

Louise Turner

5University of Copenhagen, Copenhagen, Greater Copenhagen, Denmark

Amaia V Bermejo

1HERVOLUTION Therapeutics, COPENHAGEN, Greater Copenhagen, Denmark

Isabella Skandorff

1HERVOLUTION Therapeutics, COPENHAGEN, Greater Copenhagen, Denmark

Lasse Neukirch

1HERVOLUTION Therapeutics, COPENHAGEN, Greater Copenhagen, Denmark

Jasmin Gille

2University of Regensburg, Regensburg, Bayern, Germany

Frederik O Bagger

3Rigshospitalet, Copenhagen, Greater Copenhagen, Denmark

Karen N Nielsen

4HERVOLUTION Therapeutics, Copenhagen, Greater Copenhagen, Denmark

Joana Daradoumis

4HERVOLUTION Therapeutics, Copenhagen, Greater Copenhagen, Denmark

Charlie R Ince

4HERVOLUTION Therapeutics, Copenhagen, Greater Copenhagen, Denmark

Lara Duvnjak

5University of Copenhagen, Copenhagen, Greater Copenhagen, Denmark

Mikkel D Müller

4HERVOLUTION Therapeutics, Copenhagen, Greater Copenhagen, Denmark

Silke Schrödel

6Perkin Elmer, Munich, Bayern, Germany

Kaare Grunddal

5University of Copenhagen, Copenhagen, Greater Copenhagen, Denmark

Kristoffer Staahl Rohrberg

8Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

Christian Thirion

6Perkin Elmer, Munich, Bayern, Germany

Anne-Marie Andersson

9InProTher, Copenhagen, Greater Copenhagen, Denmark

Emeline Ragonnaud

4HERVOLUTION Therapeutics, Copenhagen, Greater Copenhagen, Denmark