Nature Communications (May 2021)
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
- Scott E. Youlten,
- John P. Kemp,
- John G. Logan,
- Elena J. Ghirardello,
- Claudio M. Sergio,
- Michael R. G. Dack,
- Siobhan E. Guilfoyle,
- Victoria D. Leitch,
- Natalie C. Butterfield,
- Davide Komla-Ebri,
- Ryan C. Chai,
- Alexander P. Corr,
- James T. Smith,
- Sindhu T. Mohanty,
- John A. Morris,
- Michelle M. McDonald,
- Julian M. W. Quinn,
- Amelia R. McGlade,
- Nenad Bartonicek,
- Matt Jansson,
- Konstantinos Hatzikotoulas,
- Melita D. Irving,
- Ana Beleza-Meireles,
- Fernando Rivadeneira,
- Emma Duncan,
- J. Brent Richards,
- David J. Adams,
- Christopher J. Lelliott,
- Robert Brink,
- Tri Giang Phan,
- John A. Eisman,
- David M. Evans,
- Eleftheria Zeggini,
- Paul A. Baldock,
- J. H. Duncan Bassett,
- Graham R. Williams,
- Peter I. Croucher
Affiliations
- Scott E. Youlten
- Bone Biology, Garvan Institute of Medical Research
- John P. Kemp
- University of Queensland Diamantina Institute, UQ
- John G. Logan
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Elena J. Ghirardello
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Claudio M. Sergio
- Bone Biology, Garvan Institute of Medical Research
- Michael R. G. Dack
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Siobhan E. Guilfoyle
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Victoria D. Leitch
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Natalie C. Butterfield
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Davide Komla-Ebri
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Ryan C. Chai
- Bone Biology, Garvan Institute of Medical Research
- Alexander P. Corr
- Bone Biology, Garvan Institute of Medical Research
- James T. Smith
- Bone Biology, Garvan Institute of Medical Research
- Sindhu T. Mohanty
- Bone Biology, Garvan Institute of Medical Research
- John A. Morris
- New York Genome Center
- Michelle M. McDonald
- Bone Biology, Garvan Institute of Medical Research
- Julian M. W. Quinn
- Bone Biology, Garvan Institute of Medical Research
- Amelia R. McGlade
- Bone Biology, Garvan Institute of Medical Research
- Nenad Bartonicek
- Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Matt Jansson
- Viapath Genetics Laboratory, Viapath Analytics LLP, Guy’s Hospital
- Konstantinos Hatzikotoulas
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Melita D. Irving
- Department of Clinical Genetics, Guy’s and St Thomas’ NHS Trust
- Ana Beleza-Meireles
- Department of Clinical Genetics, University Hospitals Bristol
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus, MC
- Emma Duncan
- Faculty of Life Sciences and Medicine, Department of Twin Research & Genetic Epidemiology, School of Life Course Sciences, King’s College London
- J. Brent Richards
- Faculty of Life Sciences and Medicine, Department of Twin Research & Genetic Epidemiology, School of Life Course Sciences, King’s College London
- David J. Adams
- Wellcome Sanger Institute
- Christopher J. Lelliott
- Wellcome Sanger Institute
- Robert Brink
- St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney
- Tri Giang Phan
- St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney
- John A. Eisman
- Bone Biology, Garvan Institute of Medical Research
- David M. Evans
- University of Queensland Diamantina Institute, UQ
- Eleftheria Zeggini
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Paul A. Baldock
- Bone Biology, Garvan Institute of Medical Research
- J. H. Duncan Bassett
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Graham R. Williams
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Peter I. Croucher
- Bone Biology, Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-021-22517-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.
