International Journal of Molecular Sciences (Sep 2023)
Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease
- Belén Callejón-Leblic,
- Saida Sánchez Espirilla,
- Carolina Gotera-Rivera,
- Rafael Santana,
- Isabel Díaz-Olivares,
- José M. Marín,
- Ciro Casanova Macario,
- Borja García Cosio,
- Antonia Fuster,
- Ingrid Solanes García,
- Juan P. de-Torres,
- Nuria Feu Collado,
- Carlos Cabrera Lopez,
- Carlos Amado Diago,
- Amparo Romero Plaza,
- Luis Alejandro Padrón Fraysse,
- Eduardo Márquez Martín,
- Margarita Marín Royo,
- Eva Balcells Vilarnau,
- Antonia Llunell Casanovas,
- Cristina Martínez González,
- Juan Bautista Galdíz Iturri,
- Celia Lacárcel Bautista,
- José Luis Gómez-Ariza,
- Antonio Pereira-Vega,
- Luis Seijo,
- José Luis López-Campos,
- Germán Peces-Barba,
- Tamara García-Barrera
Affiliations
- Belén Callejón-Leblic
- Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain
- Saida Sánchez Espirilla
- Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain
- Carolina Gotera-Rivera
- IIS-Jiménez Díaz Foundation, ISCIII-CIBERES, Reyes Católicos Ave., 28040 Madrid, Spain
- Rafael Santana
- IIS-Jiménez Díaz Foundation, ISCIII-CIBERES, Reyes Católicos Ave., 28040 Madrid, Spain
- Isabel Díaz-Olivares
- Beturia Andalusian Foundation for Health Research (FABIS), Ronda Norte, s/n, 21005 Huelva, Spain
- José M. Marín
- Miguel Servet Hospital-IIS Aragon, ISCIII-CIBERES, Paseo de Isabel la Católica, 1-3, 50009 Zaragoza, Spain
- Ciro Casanova Macario
- Pulmonary Department—Research Unit, Hospital Universitario Nuestra Señora de Candelaria, CIBERES, ISCIII, Universidad de La Laguna, Padre Herrera, s/n, 38200 Santa Cruz de Tenerife, Spain
- Borja García Cosio
- Son Espases Hospital, IdISBa, ISCIII-CIBERES, Valldemossa Road, 79, 07120 Palma De Mallorca, Spain
- Antonia Fuster
- Son Llàtzer Hospital, C. de Manacor, 07198 Palma, Spain
- Ingrid Solanes García
- Santa Creu i Sant Pau Hospital, Carrer de St. Antoni Maria Claret, 167, 08025 Barcelona, Spain
- Juan P. de-Torres
- University Clinic of Navarra, Pío XII Ave., 36, 31008 Pamplona, Spain
- Nuria Feu Collado
- Reina Sofía Hospital, Maimonides Institute for Biomedical Research of Córdoba, Menéndez Pidal Ave., s/n, 14004 Córdoba, Spain
- Carlos Cabrera Lopez
- University Hospital of Gran Canaria Dr. Negrín, Respiratory Service, C. Pl. Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canarias, Spain
- Carlos Amado Diago
- Valdecilla Hospital, Valdecilla, s/n, 39008 Santander, Spain
- Amparo Romero Plaza
- Manacor Hospital, Manacor Alcudia Road, s/n, 07500 Manacor, Spain
- Luis Alejandro Padrón Fraysse
- Pneumology Area of the Juan Ramón Jiménez Hospital, Ronda Norte, s/n, 21005 Huelva, Spain
- Eduardo Márquez Martín
- Virgen del Rocío Hospital, Institute of Biomedicine of Seville (IBiS), ISCIII-CIBERES, Manuel Siurot Ave., s/n, 41013 Seville, Spain
- Margarita Marín Royo
- Castellón Hospital, Benicàssim Ave., 128, 12004 Castellón, Spain
- Eva Balcells Vilarnau
- Hospital del Mar, ISCIII-CIBERES, Paseo Marítimo de la Barceloneta, 25, 29, 08003 Barcelona, Spain
- Antonia Llunell Casanovas
- Terrassa Hospital, Torrebonica Road, s/n, 08227 Barcelona, Spain
- Cristina Martínez González
- Central Hospital of Asturias, Roma Ave., s/n, 33011 Oviedo, Spain
- Juan Bautista Galdíz Iturri
- Cruces University Hospital, ISCIII-CIBERES, Cruces Plaza, s/n, 48903 Baracaldo, Spain
- Celia Lacárcel Bautista
- Jaén University Hospital, Av. del Ejército Español, 10, 23007 Jaén, Spain
- José Luis Gómez-Ariza
- Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain
- Antonio Pereira-Vega
- Pneumology Area of the Juan Ramón Jiménez Hospital, Ronda Norte, s/n, 21005 Huelva, Spain
- Luis Seijo
- University Clinic of Navarra, ISCIII-CIBERES, Monforte de Lemos Ave., 28029 Madrid, Spain
- José Luis López-Campos
- Medical-Surgical Unit for Respiratory Diseases, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, University of Seville, Manuel Siurot Ave., s/n, 41013 Sevilla, Spain
- Germán Peces-Barba
- IIS-Jiménez Díaz Foundation, ISCIII-CIBERES, Reyes Católicos Ave., 28040 Madrid, Spain
- Tamara García-Barrera
- Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain
- DOI
- https://doi.org/10.3390/ijms241814250
- Journal volume & issue
-
Vol. 24,
no. 18
p. 14250
Abstract
Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
Keywords
- lung cancer
- chronic obstructive pulmonary disease
- metals
- inductively coupled plasma
- metallomics
- mass spectrometry