Nature Communications (Jan 2020)
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
- Tom Sidwell,
- Yang Liao,
- Alexandra L. Garnham,
- Ajithkumar Vasanthakumar,
- Renee Gloury,
- Jonas Blume,
- Peggy P. Teh,
- David Chisanga,
- Christoph Thelemann,
- Fabian de Labastida Rivera,
- Christian R. Engwerda,
- Lynn Corcoran,
- Kohei Kometani,
- Tomohiro Kurosaki,
- Gordon K. Smyth,
- Wei Shi,
- Axel Kallies
Affiliations
- Tom Sidwell
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Yang Liao
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Alexandra L. Garnham
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Ajithkumar Vasanthakumar
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Renee Gloury
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Jonas Blume
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Peggy P. Teh
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- David Chisanga
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Christoph Thelemann
- Molecular Immunology, Walter and Eliza Hall Institute of Medical Research
- Fabian de Labastida Rivera
- QIMR Berghofer Medical Research Institute
- Christian R. Engwerda
- QIMR Berghofer Medical Research Institute
- Lynn Corcoran
- Molecular Immunology, Walter and Eliza Hall Institute of Medical Research
- Kohei Kometani
- Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS)
- Tomohiro Kurosaki
- Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS)
- Gordon K. Smyth
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Wei Shi
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Axel Kallies
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-019-14112-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.
